Physical activity (PA) and exercise training (ET) are central and indispensable components for primary and secondary prevention of cardiovascular disease (CVD). In healthy individuals, PA reduces all-cause and CV mortality and has confirmed beneficial effects on the cardiovascular risk profile. In secondary prevention, PA counselling und ET are two of the core components of a multidisciplinary cardiac rehabilitation (CR) program. Exercise-based CR is an established strategy in the secondary prevention of CV disease. It improves survival, reduces hospital admissions, improves cardiorespiratory fitness (CRF), and quality of life (QoL).