Background: We aimed to develop a physical activity prescription (PAP) that would help efficiently promote PA by medical practitioners in Luxembourg. Methods: During a first phase, a PAP model and its user guide were created by 15 experts (medical doctors, sport and exercise scientists, physiotherapists). Second, this PAP and its user guide were evaluated by a panel of medical doctors (different from the 15 experts) who were asked to answer a questionnaire in 2 rounds using 41 questions and 2 questions, respectively.