Non-steroidal anti-inflammatory drugs (NSAIDs) have the highest intake of all medication in elite and non-elite athletes. The high consumption by athletes (30–50%) participating in team and single-sports leads to the assumption that not only injuries are being treated, but that masking symptoms of minor complaints or post-exercise fatigue might be the primary indication for their intake, without considering their potential harmful side-effects on general health but also on training adaptive processes.